Neurocrine Biosciences Inc

NBIX · Health care (biological products, (no diagnostic substances)) · 10 years of annual accounts filed with the SEC · latest fiscal year ended 2025-12-31

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Neurocrine Biosciences Inc reported revenue of $2.9 billion in fiscal 2025, after growing 79.2% a year over the previous 9 years. Its operating margin widened from -982.5% in 2016 to 21.6%. Of the $2.6 billion its operations generated over 10 years, 17.7% went to buybacks and 7.6% back into the business; the share count rose 18.2%. On the accounting screens, it passes 5 of 8 Piotroski tests, its Altman Z'' of 6.21 is in the safe zone and its Beneish M-score is below the -1.78 line; 1 of the six cross-checks between its statements fires.

Revenue, fiscal 2025 2.9B +79.2% a year over 9 years

Operating margin 21.6% gross margin 98.2%

Return on invested capital —

Free cash flow after stock pay 530.8M 18.6% of revenue

Net debt ÷ EBITDA — net debt —

Piotroski F-score 5/8 tests of improvement passed

Is it growing?

Revenue and the operating income it turns into. Growth that does not reach operating income is growth bought with margin.

RevenueOperating income

Compound growth a year
	3 yrs	5 yrs	9 yrs
Revenue	+24.3%	+22.3%	+79.2%
Operating income	+35.5%	+30.6%	—
Net income	+45.8%	+3.3%	—
Earnings per share	+44.0%	+2.3%	—
Free cash flow per share	+30.8%	+26.8%	—
Shares	+1.2%	+0.9%	+1.9%

Falling shares are buybacks: each remaining share owns more of the company.

Does it earn more than its capital costs?

Margins say how much of each sale is kept; return on invested capital says how much the business earns on the money it needs to operate. Growth only creates value when that return is above the cost of the capital.

    GrossOperatingNetFree cash flow
    
  

Return on invested capital

Economic profit

Needs a cost of capital, which comes from the valuation below.

Return on equity: 14.7%
Return on assets: 10.3%
Asset turnover: 0.62×
Research & development: 35.5% of revenue
Overheads (SG&A): 40.4% of revenue

Is the profit cash, and where does the cash go?

Net income is an accounting opinion; free cash flow is what was left in the bank after investing. Stock-based pay does not leave the bank — shareholders pay it through dilution — so it is shown taken off as well.

Net incomeFree cash flowAfter stock-based pay

Where 10 years of operating cash went, 2016–2025

2.6B generated by the business. Each band is its share of that total.

Reinvested in the business 8% 201.8M
Acquisitions 2% 42.7M
Dividends 0% 0
Share buybacks 18% 467.7M
Kept, or used to pay down debt 73% 1.9B

Over the same years it paid 1.2B in stock. The share count rose 18.2%. The buybacks did not even cover what was handed out in stock.

Per share

    Earnings per shareFree cash flow per shareDividend per share
    
  

Shares outstanding

Diluted shares

Debt and liquidity

Debt is not bad in itself; debt the business cannot service in a bad year is. Net debt is debt minus cash, and below zero the company holds more cash than it owes.

Net debt ÷ EBITDA: —
Interest coverage: — operating income ÷ interest
Current ratio: 3.39 current assets ÷ current liabilities
Cash conversion cycle: — collects in 88d

Three classic screens of the accounts

Each asks a different question of the same statements — is it improving, does it look like a company heading for distress, do the accounts resemble ones that were manipulated. None is a verdict; each shows what moves it.

Piotroski F-score

Is the business improving? Nine yes-or-no tests, this year against last.

5of 8 tests passed

ProfitableReturn on assets above zero passed
Cash from operationsOperating cash flow above zero passed
Profitability improvedReturn on assets higher than a year before passed
Profit backed by cashOperating cash flow above net income (low accruals) passed
Less long-term debtLong-term debt as a share of assets fell — not reported no data
More liquidCurrent ratio higher than a year before failed
No new sharesShare count did not grow passed
Better gross marginGross margin higher than a year before failed
Sells more per assetAsset turnover higher than a year before failed

Where it misleads: it measures change, not level. An excellent business that stood still for a year scores low; a poor one recovering from a disaster scores high.

Altman Z''-score

Does the balance sheet look like those of companies that went bankrupt?

6.21safe zone

Working capital ÷ assets 0.38 × 6.56+2.52
Retained earnings ÷ assets 0.10 × 3.26+0.32
Operating income ÷ assets 0.13 × 6.72+0.90
Equity ÷ liabilities 2.36 × 1.05+2.48

Where it misleads: buybacks. A company that returns so much cash that its equity turns small or negative sinks the last two ratios without being anywhere near bankruptcy. Banks and insurers do not fit the model at all.

Beneish M-score

Do the accounts resemble those of companies that manipulated their earnings?

-2.54below the -1.78 line

Receivables vs sales 1.18+1.09
Gross margin slipping 1.00+0.53
Soft assets 0.85+0.34
Sales growth 1.21+1.08
Slower depreciation 0.99+0.11
Overheads vs sales 0.95-0.16
Profit not in cash -0.07-0.31
Leverage rising 1.18-0.38

Where it misleads: fast growth and acquisitions. Sales growth carries a heavy weight, so a company growing 50% a year scores like a suspect without having done anything. It is a screen from a 1999 study, not an accusation.

Where the statements disagree

Cross-checks between the income statement, the balance sheet and the cash flow for the latest year, each with the benign reading and the worrying one.

Receivables are growing 43% against revenue growing 21%.

Benign

A shift towards larger customers on longer terms, or sales concentrated at the end of the period.

Worrying

Sales are being made on looser credit, or revenue has been booked that may never be collected.

What is it worth, under which assumptions?

A company is worth the cash it will generate, brought back to today. This model projects revenue with growth that fades over the years, applies a free cash flow margin, and discounts the result at the cost of capital. Every assumption says where it came from, and all of them can be changed.

Revenue

Starting revenue

M $

revenue of fiscal 2025

Growth in year one

revenue grew +22.3% a year over the last 5 years; it fades to the terminal rate by the last year

Years until it settles

yrs

ten years for growth to fade to the terminal rate

Cash from each sale

Free cash flow margin today

free cash flow to the firm after stock-based pay ÷ revenue, last 3 fiscal years together

Margin in the last year

the margin in year ten; by default the business keeps today's

Count stock-based pay as a costIt is paid in shares instead of cash, and shareholders bear it through dilution. Most free cash flow figures leave it out.

The long run

Growth after that, forever

growth forever after year ten, below the risk-free rate: no company outgrows the economy forever

The discount rate

Risk-free rate

10-year US Treasury par yield (U.S. Treasury), 2026-09-29

Beta

not measured on this public page, which uses only public filings: 1.0 assumes it moves like the market. Sign in to measure it from prices

Equity risk premium

the extra return demanded for holding shares; it cannot be measured, and 4–6% is the common range

Cost of debt, before tax

no interest line: the risk-free rate + 1.5 points

Tax rate

effective rate in the last fiscal year, 32.2%, kept within 0–35%

The price

Share price

Type the price you see at your broker. It is used only for the reverse questions: what that price implies.

Back to the defaults

SEC from the filings Treasury the 10-year yield measured from prices assumption cannot be measured yours you changed it

With a free cash flow margin at or below zero in year ten, the business never generates cash for its owners and a DCF says nothing useful. Set a positive margin for year ten to see what it would take.

What it has filed lately

The last twelve months at the SEC, most important first: annual and quarterly reports, events, large holders and insiders.

Event 2026-09-28

Changed a director or officer

Changed a director or officer; published the results of a shareholder vote

Event 2026-05-18

Signed a material agreement; completed an acquisition or disposal; took on a financial obligation; published information for investors

Signed a material agreement

Estimatein 33d

Results for the period ending 2026-09-29

What its own directors and officers did

Every Form 4 filed in the last twelve months, read line by line: 10 filings by 10 people. Open-market purchases and sales are counted apart from awards, option exercises and shares withheld for taxes.

Bought on the open market—none in the period

Sold on the open market$493,3352 sale(s) by 2 insider(s)

Under pre-arranged plans100%of the sales followed a 10b5-1 plan set months earlier

Other lines2211 awards · 0 option exercises · 11 tax withholdings

Date	Who	What	Shares	Price	Value	Holds after
14 Sep 2026	Boyer David W.Chief Corp. Affairs Officer	Sold on the open market · pre-arranged plan	826	$157.45	$130,051	8,722
14 Sep 2026	Abernethy MattChief Financial Officer	Sold on the open market · pre-arranged plan	2,311	$157.20	$363,285	42,808
11 Sep 2026	Lippoldt DarinChief Legal Officer	Received as an award	4,483	—	—	59,212
11 Sep 2026	Lippoldt DarinChief Legal Officer	Shares withheld for taxes	2,419	$156.22	$377,896	56,793
11 Sep 2026	Keswani Sanjay ChandruChief Medical Officer	Received as an award	3,914	—	—	5,393
11 Sep 2026	Keswani Sanjay ChandruChief Medical Officer	Shares withheld for taxes	2,112	$156.22	$329,937	3,281
11 Sep 2026	Gorman Kevin CharlesDirector	Received as an award	14,343	—	—	525,636
11 Sep 2026	Gorman Kevin CharlesDirector	Shares withheld for taxes	7,839	$156.22	$1.2M	517,797
11 Sep 2026	Gano KyleChief Executive Officer	Received as an award	6,275	—	—	157,266
11 Sep 2026	Gano KyleChief Executive Officer	Shares withheld for taxes	3,386	$156.22	$528,961	153,880
11 Sep 2026	Gano KyleChief Executive Officer	Received as an award	1,842	—	—	155,722
11 Sep 2026	Gano KyleChief Executive Officer	Shares withheld for taxes	994	$156.22	$155,283	154,728
11 Sep 2026	Onyia JudeChief Scientific Officer	Received as an award	3,587	—	—	24,583
11 Sep 2026	Delaet IngridChief Regulatory Officer	Shares withheld for taxes	2,419	$156.22	$377,896	18,289
11 Sep 2026	Cooke JulieChief Human Resources Officer	Received as an award	3,587	—	—	25,961
11 Sep 2026	Cooke JulieChief Human Resources Officer	Shares withheld for taxes	1,936	$156.22	$302,442	24,025
11 Sep 2026	Boyer David W.Chief Corp. Affairs Officer	Received as an award	3,587	—	—	11,484
11 Sep 2026	Boyer David W.Chief Corp. Affairs Officer	Shares withheld for taxes	1,936	$156.22	$302,442	9,548
11 Sep 2026	Benevich EricChief Commercial Officer	Received as an award	6,275	—	—	70,683
11 Sep 2026	Benevich EricChief Commercial Officer	Shares withheld for taxes	3,386	$156.22	$528,961	67,297
11 Sep 2026	Abernethy MattChief Financial Officer	Received as an award	5,020	—	—	47,828
11 Sep 2026	Abernethy MattChief Financial Officer	Shares withheld for taxes	2,709	$156.22	$423,200	45,119
11 Sep 2026	Delaet IngridChief Regulatory Officer	Received as an award	4,483	—	—	20,708
11 Sep 2026	Onyia JudeChief Scientific Officer	Shares withheld for taxes	1,936	$156.22	$302,442	22,647

A Form 4 says what happened, when, how many shares and at what price. It does not say why: a sale can be diversification, a tax bill or a plan fixed months earlier, and an award is pay, not a purchase. Nothing here is a reason to buy or sell anything.

Which large funds report holding it

From the Form 13F of the 28 institutions followed on this site, as of the end of their last reported quarter. A 13F is filed up to 45 days later and shows only long positions in US-listed shares.

Fund	Shares	Value	Share of the fund	Since the quarter before
Dodge & Cox 30 Jun 2026	5.6M	$941.2M	0.5%	Added to
Norges Bank (Norway's sovereign fund) 30 Jun 2026	973,880	$164.1M	0.0%	New
Bridgewater Associates 30 Jun 2026	205,677	$34.7M	0.1%	Added to

All the funds and what they reported ›

Companies like this one

Same SEC industry (biological products, (no diagnostic substances)) first, then the rest of health care.

AMGN Amgen Inc GILD Gilead Sciences, Inc.MRNA Moderna, Inc.RVMD Revolution Medicines, Inc.BIIB Biogen Inc.EXEL Exelixis, Inc.HALO Halozyme Therapeutics, Inc.TECH BIO-TECHNE Corp

Every figure, year by year

10 fiscal years · 30 measures

	2016	2017	2018	2019	2020	2021	2022	2023	2024	2025
Size
Revenue	15.0M	161.6M	451.2M	788.1M	1.0B	1.1B	1.5B	1.9B	2.4B	2.9B
Revenue growth	—	+977.5%	+179.2%	+74.7%	+32.7%	+8.4%	+31.3%	+26.8%	+24.8%	+21.4%
Operating income	-147.4M	-131.4M	36.8M	72.3M	163.0M	102.5M	249.0M	250.9M	570.5M	619.1M
Net income	-141.1M	-142.5M	21.1M	37.0M	407.3M	89.6M	154.5M	249.7M	341.3M	478.6M
Margins
Gross margin	100.0%	99.2%	98.9%	—	99.0%	98.7%	98.4%	97.9%	98.6%	98.2%
Operating margin	-982.5%	-81.3%	8.2%	9.2%	15.6%	9.0%	16.7%	13.3%	24.2%	21.6%
Net margin	-940.6%	-88.2%	4.7%	4.7%	38.9%	7.9%	10.4%	13.2%	14.5%	16.7%
Free cash flow margin	-735.3%	-62.7%	17.0%	16.8%	20.8%	20.6%	21.7%	19.2%	23.7%	26.2%
R&D ÷ revenue	628.6%	75.4%	35.6%	—	26.3%	28.9%	31.2%	29.9%	31.0%	35.5%
SG&A ÷ revenue	453.9%	105.1%	55.2%	44.9%	41.4%	51.5%	50.6%	47.0%	42.8%	40.4%
Cash
Free cash flow	-110.3M	-101.3M	76.6M	132.3M	217.6M	233.1M	322.9M	361.6M	557.2M	748.7M
Stock-based pay	28.5M	42.5M	58.1M	75.3M	100.0M	134.2M	173.1M	194.3M	195.5M	217.9M
Free cash flow after stock pay	-138.8M	-143.8M	18.5M	57.0M	117.6M	98.9M	149.8M	167.3M	361.7M	530.8M
Free cash flow to the firm	-150.0M	-167.5M	-13.1M	-39.2M	-339.7M	47.2M	9.4M	85.6M	327.0M	192.7M
Free cash flow ÷ net income	0.8×	0.7×	3.6×	3.6×	0.5×	2.6×	2.1×	1.4×	1.6×	1.6×
Capex ÷ revenue	27.4%	4.3%	5.5%	1.9%	1.0%	2.1%	1.1%	1.5%	1.6%	1.2%
Returns
Return on invested capital	—	—	—	—	—	—	—	—	—	—
Return on equity	-44.8%	-38.3%	4.4%	5.8%	36.2%	6.5%	9.0%	11.2%	13.2%	14.7%
Return on assets	-38.6%	-17.4%	2.1%	2.8%	23.5%	4.3%	6.5%	7.7%	9.2%	10.3%
Asset turnover	0.0×	0.2×	0.5×	0.6×	0.6×	0.5×	0.6×	0.6×	0.6×	0.6×
Economic profit	—	—	—	—	—	—	—	—	—	—
Per share
Earnings per share	$-1.63	$-1.62	$0.22	$0.39	$4.16	$0.92	$1.56	$2.47	$3.29	$4.67
Free cash flow per share	$-1.27	$-1.15	$0.80	$1.38	$2.22	$2.38	$3.26	$3.58	$5.37	$7.30
Dividend per share	—	—	—	—	—	—	—	—	—	—
Payout ratio	—	—	—	—	—	—	—	—	—	—
Book value per share	$3.62	$4.19	$5.30	$6.90	$12.04	$14.48	$17.70	$22.61	$26.05	$32.50
Diluted shares	86.7M	88.1M	95.4M	95.7M	97.8M	97.9M	98.9M	101.0M	103.7M	102.5M
Balance sheet
Net debt	—	—	—	—	—	—	—	—	—	—
Net debt ÷ EBITDA	—	—	—	—	—	—	—	—	—	—
Interest coverage	—	-6.7×	1.2×	2.3×	5.0×	4.0×	35.1×	54.5×	—	—
Current ratio	10.2×	10.2×	8.4×	1.5×	5.4×	4.0×	2.7×	2.5×	3.4×	3.4×
Cash conversion cycle (days)	—	-1,276	-173	—	—	—	—	—	—	—
Scores
Piotroski F-score	—	3	5	5	4	3	5	4	7	5
Altman Z''	-0.53	-0.97	1.66	-0.12	4.35	3.70	5.40	4.58	5.61	6.21
Beneish M	—	6.70	-1.63	-3.04	-1.45	-2.65	-2.60	-2.26	-2.56	-2.54

Accounts from the company's own SEC filings; lines some companies do not report are shown as a dash rather than estimated. The risk-free rate is the 10-year US Treasury yield. A DCF is a way of making assumptions explicit, not a forecast: it states what the company would be worth if the assumptions held. The scores are screens that point where to look, not verdicts. Nothing here is a recommendation to buy or sell.