Vertex Pharmaceuticals Inc / MA

VRTX · Health care (pharmaceutical preparations) · 10 years of annual accounts filed with the SEC · latest fiscal year ended 2025-12-31

Vertex Pharmaceuticals Inc / MA reported revenue of $12.0 billion in fiscal 2025. Of the $19.5 billion its operations generated over 10 years, 31.3% went to buybacks and 9.2% back into the business. On the accounting screens, it passes 5 of 8 Piotroski tests, its Altman Z'' of 7.50 is in the safe zone and its Beneish M-score is below the -1.78 line; 2 of the six cross-checks between its statements fire.

Revenue, fiscal 2025 12.0B

Operating margin 34.8% gross margin 86.2%

Return on invested capital —

Free cash flow after stock pay 2.5B 20.9% of revenue

Net debt ÷ EBITDA — net debt —

Piotroski F-score 5/8 tests of improvement passed

Is it growing?

Revenue and the operating income it turns into. Growth that does not reach operating income is growth bought with margin.

RevenueOperating income

Compound growth a year
	3 yrs	5 yrs	9 yrs
Revenue	+10.4%	+14.1%	—
Operating income	-1.0%	+7.9%	—
Net income	+6.0%	+7.8%	—
Earnings per share	+6.1%	+8.3%	—
Free cash flow per share	-6.5%	+1.7%	—
Shares	-0.1%	-0.4%	—

Falling shares are buybacks: each remaining share owns more of the company.

Does it earn more than its capital costs?

Margins say how much of each sale is kept; return on invested capital says how much the business earns on the money it needs to operate. Growth only creates value when that return is above the cost of the capital.

    GrossOperatingNetFree cash flow
    
  

Return on invested capital

Return on invested capital Cost of capital today · 10.2%

Economic profit

Needs a cost of capital, which comes from the valuation below.

Return on equity: 21.2%
Return on assets: 15.4%
Asset turnover: 0.47×
Research & development: 32.6% of revenue
Overheads (SG&A): 14.6% of revenue

Is the profit cash, and where does the cash go?

Net income is an accounting opinion; free cash flow is what was left in the bank after investing. Stock-based pay does not leave the bank — shareholders pay it through dilution — so it is shown taken off as well.

Net incomeFree cash flowAfter stock-based pay

Where 10 years of operating cash went, 2018–2025

19.5B generated by the business. Each band is its share of that total.

Reinvested in the business 9% 1.8B
Acquisitions 7% 1.5B
Dividends 0% 0
Share buybacks 31% 6.1B
Kept, or used to pay down debt 52% 10.2B

Over the same years it paid 4.0B in stock. 2.1B of the buybacks went beyond offsetting that dilution.

Per share

    Earnings per shareFree cash flow per shareDividend per share
    
  

Shares outstanding

Diluted shares

How strong is the balance sheet?

Debt is not bad in itself; debt the business cannot service in a bad year is. Net debt is debt minus cash, and below zero the company holds more cash than it owes.

Net debt ÷ EBITDA: —
Interest coverage: 314× operating income ÷ interest
Current ratio: 2.90 current assets ÷ current liabilities
Cash conversion cycle: 333 days collects in 62d, stock 373d, pays in 102d

Three classic screens of the accounts

Each asks a different question of the same statements — is it improving, does it look like a company heading for distress, do the accounts resemble ones that were manipulated. None is a verdict; each shows what moves it.

Piotroski F-score

Is the business improving? Nine yes-or-no tests, this year against last.

5of 8 tests passed

ProfitableReturn on assets above zero passed
Cash from operationsOperating cash flow above zero passed
Profitability improvedReturn on assets higher than a year before passed
Profit backed by cashOperating cash flow above net income (low accruals) failed
Less long-term debtLong-term debt as a share of assets fell — not reported no data
More liquidCurrent ratio higher than a year before passed
No new sharesShare count did not grow failed
Better gross marginGross margin higher than a year before passed
Sells more per assetAsset turnover higher than a year before failed

Where it misleads: it measures change, not level. An excellent business that stood still for a year scores low; a poor one recovering from a disaster scores high.

Altman Z''-score

Does the balance sheet look like those of companies that went bankrupt?

7.50safe zone

Working capital ÷ assets 0.29 × 6.56+1.88
Retained earnings ÷ assets 0.53 × 3.26+1.72
Operating income ÷ assets 0.16 × 6.72+1.09
Equity ÷ liabilities 2.68 × 1.05+2.81

Where it misleads: buybacks. A company that returns so much cash that its equity turns small or negative sinks the last two ratios without being anywhere near bankruptcy. Banks and insurers do not fit the model at all.

Beneish M-score

Do the accounts resemble those of companies that manipulated their earnings?

-2.19below the -1.78 line

Receivables vs sales 1.17+1.08
Gross margin slipping 1.00+0.53
Soft assets 1.00 (not reported, set to 1)+0.40
Sales growth 1.09+0.97
Slower depreciation 1.00 (not reported, set to 1)+0.12
Overheads vs sales 1.10-0.19
Profit not in cash 0.01+0.06
Leverage rising 0.95-0.31

Where it misleads: fast growth and acquisitions. Sales growth carries a heavy weight, so a company growing 50% a year scores like a suspect without having done anything. It is a screen from a 1999 study, not an accusation.

Where the statements disagree

Cross-checks between the income statement, the balance sheet and the cash flow for the latest year, each with the benign reading and the worrying one.

Receivables are growing 28% against revenue growing 9%.

Benign

A shift towards larger customers on longer terms, or sales concentrated at the end of the period.

Worrying

Sales are being made on looser credit, or revenue has been booked that may never be collected.

Inventory is growing 40% against revenue growing 9%.

Benign

Stocking up for a launch, or securing supply.

Worrying

Demand is softening; discounts or write-downs tend to follow.

What is it worth, under which assumptions?

A company is worth the cash it will generate, brought back to today. This model projects revenue with growth that fades over the years, applies a free cash flow margin, and discounts the result at the cost of capital. Every assumption says where it came from, and all of them can be changed.

Revenue

Starting revenue

M $

revenue of fiscal 2025

Growth in year one

revenue grew +14.1% a year over the last 5 years; it fades to the terminal rate by the last year

Years until it settles

yrs

ten years for growth to fade to the terminal rate

Cash from each sale

Free cash flow margin today

free cash flow to the firm after stock-based pay ÷ revenue, last 3 fiscal years together

Margin in the last year

the margin in year ten; by default the business keeps today's

Count stock-based pay as a costIt is paid in shares instead of cash, and shareholders bear it through dilution. Most free cash flow figures leave it out.

The long run

Growth after that, forever

growth forever after year ten, below the risk-free rate: no company outgrows the economy forever

The discount rate

Risk-free rate

10-year US Treasury yield (FRED, DGS10), 2026-09-24

Beta

not measured on this public page, which uses only public filings: 1.0 assumes it moves like the market. Sign in to measure it from prices

Equity risk premium

the extra return demanded for holding shares; it cannot be measured, and 4–6% is the common range

Cost of debt, before tax

no interest line: the risk-free rate + 1.5 points

Tax rate

effective rate in the last fiscal year, 14.9%, kept within 0–35%

The price

Share price

Type the price you see at your broker. It is used only for the reverse questions: what that price implies.

Back to the defaults

SEC from the filings Treasury the 10-year yield measured from prices assumption cannot be measured yours you changed it

Value per share, with these assumptions $96.79 discounted at 10.2% a year · 53% of it from after year 10

$70.8080% of 5,000 simulations$133.59

Cautious $62.01 10.0% growth · 8.4% margin · 11.2% discount · 2.0% forever

Your assumptions $96.79 14.0% growth · 9.9% margin · 10.2% discount · 2.5% forever

Generous $157.95 18.0% growth · 11.3% margin · 9.2% discount · 3.0% forever

Type a share price on the left to ask the reverse questions: what growth, what margin or what discount rate that price implies.

What the value implies, in the usual multiples

	At this model's value
Price ÷ earnings	6.3×
Enterprise value ÷ EBITDA	5.7×
Enterprise value ÷ revenue	2.1×
Free cash flow yield	10.0%

From cash flows to a value per share

10 years of cash flow, today11.8B

Everything after, today13.1B

The whole business25.0B

Minus net debt-0

What belongs to shareholders25.0B

Divided among 258.0M shares: $96.79 each.

The projection next to its history

Reported free cash flow after stock pay, then the model's. A projection that looks nothing like the past needs a reason.

ReportedProjected

Year by year

	2026	2027	2028	2029	2030	2031	2032	2033	2034	2035
Revenue	13.7B	15.4B	17.2B	18.9B	20.6B	22.2B	23.6B	24.8B	25.7B	26.4B
Growth	14.0%	12.7%	11.4%	10.2%	8.9%	7.6%	6.3%	5.1%	3.8%	2.5%
Cash margin	9.9%	9.9%	9.9%	9.9%	9.9%	9.9%	9.9%	9.9%	9.9%	9.9%
Free cash flow	1.3B	1.5B	1.7B	1.9B	2.0B	2.2B	2.3B	2.4B	2.5B	2.6B
Worth today	1.2B	1.3B	1.3B	1.3B	1.3B	1.2B	1.2B	1.1B	1.1B	985.0M

If the least-known inputs move

Value per share as two inputs change at a time. Neighbouring cells that differ a lot are the conclusion: the value depends on numbers nobody knows to a point.

The discount rate and growth forever

discount ↓ · forever →	1.5%	2.0%	2.5%	3.0%	3.5%
9.2%	100	106	112	120	129
9.7%	93	98	104	110	118
10.2%	88	92	97	102	109
10.7%	83	86	90	95	101
11.2%	78	81	85	89	94

Year-one growth and the final margin

margin ↓ · growth →	10.0%	12.0%	14.0%	16.0%	18.0%
7.9%	70	76	82	88	95
8.9%	76	83	89	96	104
9.9%	83	89	97	105	113
10.8%	89	96	104	113	122
11.8%	95	103	112	121	131

All the inputs moving at once

5,000 valuations, each with growth, final margin, discount rate and growth forever drawn at random around the values on the left (spreads of 3.0%, 2.0%, 1.0% and 0.5%). Not a probability — the spreads are assumptions too — but an honest picture of how wide the answer is.

10th percentile$70.80

Median$97.05

90th percentile$133.59

Half of the simulations land between $81.99 and $114.26; one in ten below $70.80, one in ten above $133.59.

Does the long run make sense?

3.6×The terminal value prices the business in year 10 at 3.6 times that year's EBITDA.
4%To grow 2.5% forever while reinvesting 67% of its after-tax operating profit, the business must earn 4% on the new capital.
53%of the value comes from after year 10. The more of it, the more the answer depends on the part nobody can see.

The discount rate, taken apart

What shareholders demand (CAPM): 5.18% risk-free + 1.00 beta × 5.0% premium = 10.18%.
What lenders charge, after the tax saving on interest: 6.68% × (1 − 14.9%) = 5.69%.
Weighted by how much of each the company uses (book value (no price given)): 10.18%, the rate every future cash flow is discounted at.

What it has filed lately

The last twelve months at the SEC, most important first: annual and quarterly reports, events, large holders and insiders.

Event 2026-09-01

Changed a director or officer

Signed a material agreement; published information for investors; published other information

Event 2026-05-13

Changed a director or officer; published the results of a shareholder vote

Changed a director or officer

Estimatein 38d

Results for the period ending 2026-09-29

Companies like this one

Same SEC industry (pharmaceutical preparations) first, then the rest of health care.

LLY ELI Lilly & Co JNJ Johnson & Johnson ABBV AbbVie Inc.MRK Merck & Co., Inc.ABT Abbott Laboratories PFE Pfizer Inc BMY Bristol Myers Squibb Co REGN Regeneron Pharmaceuticals, Inc.

Every figure, year by year

10 fiscal years · 30 measures

	2018	2018	2019	2019	2020	2021	2022	2023	2024	2025
Size
Revenue	—	3.0B	—	4.2B	6.2B	7.6B	8.9B	9.9B	11.0B	12.0B
Revenue growth	—	—	—	—	+49.1%	+22.1%	+17.9%	+10.5%	+11.7%	+8.9%
Operating income	—	635.1M	—	1.2B	2.9B	2.8B	4.3B	3.8B	-232.9M	4.2B
Net income	—	2.1B	—	1.2B	2.7B	2.3B	3.3B	3.6B	-535.6M	4.0B
Margins
Gross margin	—	86.6%	—	86.8%	88.1%	88.1%	87.9%	87.2%	86.1%	86.2%
Operating margin	—	20.8%	—	28.8%	46.0%	36.7%	48.2%	38.8%	-2.1%	34.8%
Net margin	—	68.8%	—	28.3%	43.7%	30.9%	37.2%	36.7%	-4.9%	32.9%
Free cash flow margin	—	38.5%	—	35.9%	48.2%	31.8%	44.0%	33.8%	-7.2%	26.6%
R&D ÷ revenue	—	46.5%	—	42.1%	29.5%	40.3%	28.4%	32.0%	32.9%	32.6%
SG&A ÷ revenue	—	18.3%	—	15.8%	12.4%	11.1%	10.6%	11.5%	13.3%	14.6%
Cash
Free cash flow	—	1.2B	—	1.5B	3.0B	2.4B	3.9B	3.3B	-790.3M	3.2B
Stock-based pay	—	325.0M	—	360.5M	429.5M	441.4M	491.3M	581.2M	698.5M	685.9M
Free cash flow after stock pay	—	849.8M	—	1.1B	2.6B	2.0B	3.4B	2.8B	-1.5B	2.5B
Free cash flow to the firm	—	-961.3M	—	1.0B	2.0B	2.0B	3.0B	2.8B	-53.0M	2.4B
Free cash flow ÷ net income	—	0.6×	—	1.3×	1.1×	1.0×	1.2×	0.9×	1.5×	0.8×
Capex ÷ revenue	—	3.1%	—	1.8%	4.2%	3.1%	2.3%	2.0%	2.7%	3.6%
Returns
Return on invested capital	—	—	—	—	—	—	—	—	—	—
Return on equity	—	47.3%	—	19.3%	31.2%	23.2%	23.9%	20.6%	-3.3%	21.2%
Return on assets	—	33.6%	—	14.1%	23.1%	17.4%	18.3%	15.9%	-2.4%	15.4%
Asset turnover	—	0.5×	—	0.5×	0.5×	0.6×	0.5×	0.4×	0.5×	0.5×
Economic profit	—	—	—	—	—	—	—	—	—	—
Per share
Earnings per share	—	$8.09	—	$4.51	$10.29	$9.01	$12.82	$13.89	$-2.08	$15.32
Free cash flow per share	—	$4.53	—	$5.73	$11.37	$9.27	$15.15	$12.81	$-3.06	$12.38
Dividend per share	—	—	—	—	—	—	—	—	—	—
Payout ratio	—	—	—	—	—	—	—	—	—	—
Book value per share	—	$17.38	—	$23.50	$33.42	$39.69	$54.13	$68.22	$63.87	$73.49
Diluted shares	—	259.2M	—	260.7M	263.4M	259.9M	259.1M	260.5M	257.9M	258.0M
Balance sheet
Net debt	—	—	—	—	—	—	—	—	—	—
Net debt ÷ EBITDA	—	—	—	—	—	—	—	—	—	—
Interest coverage	—	8.8×	—	20.5×	49.1×	45.2×	78.6×	86.9×	-7.6×	313.8×
Current ratio	—	3.4×	—	3.6×	4.3×	4.5×	4.8×	4.0×	2.7×	2.9×
Cash conversion cycle (days)	—	61	—	109	114	119	112	166	242	333
Scores
Piotroski F-score	—	2	0	3	7	6	6	2	3	5
Altman Z''	—	4.55	—	5.85	8.34	8.97	10.01	9.23	5.89	7.50
Beneish M	—	—	—	—	-2.28	-2.32	-2.43	-2.41	-2.48	-2.19

Accounts from the company's own SEC filings; lines some companies do not report are shown as a dash rather than estimated. The risk-free rate is the 10-year US Treasury yield. A DCF is a way of making assumptions explicit, not a forecast: it states what the company would be worth if the assumptions held. The scores are screens that point where to look, not verdicts. Nothing here is a recommendation to buy or sell.